Chronic Kidney Disease (CKD) and its subsequent complications and consequences are an increasing concern in general population. A biophysical integrated approach in early stages of CKD was investigated in 30 patients with a 12-month follow-up. A clinical approach based on the use of an electro medical device (Medselect 729) was employed following previous reports as well as the procedure of electromagnetic information transfer through aqueous systems. Interestingly, we observed a significant increase in the estimated glomerular filtration rate (e GFR) according to CKD-EPI formula (+11.57 ml/min; +18.43%, p < 0.0001). Beside further studies are certainly recommended, a biophysical integrated approach in the management of early stages of Chronic Kidney Disease seems actually to be feasible, effective, and promising.