This paper presents design and implementation concepts for a wireless real-time home automation system based on Arduino Uno microcontroller as central controllers. The pro- posed system has two operational modes. The first one is denoted as a manually-automated mode in which the user can monitor and control the home appliances from anywhere over the world using the cellular phone through Wi-Fi communication technology. The second one is referred to a self-automated mode that makes the controllers to be capable of monitoring and controlling different appliances in the home automatically in response to the signals comes from the related sensors. To support the usefulness of the proposed technique, a hardware implementation with Matlab-GUI platform for the proposed system is carried out and the reliability of the system is introduced. The proposed system is shown to be a simple, cost effective and flexible that making it a suitable and a good candidate for the smart home future.