Desertification is one of the most serious problems of environment and social econ- omy in the world today, which threats to human survival safety directly. In this paper, based on MODIS-NDVI data and dimidiate pixel model, we analyzed space distribution and change characteristics of desertification in Ebinur Lake Basin. Study results indicated the sandy deser- tification in most parts of Ebinur Lake Basin was mild and moderate desertifications which were always over the 60 percent of total area, the area of micro and non-desertification had been still transforming to the area of the severe, moderate and mild desertification.